Valproic acid (by its official name 2-propylvaleric acid) was first synthesized in 1882 by Burton as an analogue of valeric acid, found naturally in Valerian. Valproic acid (VPA) has been used in the treatment of epilepsy for almost 30 years. Valproic Acid. Valproic acid (VPA) has been used in the treatment of epilepsy for almost 30 years. Predicted data is generated using the US Environmental Protection Agency’s EPISuite™. View more information in the IUPHAR Pharmacology Education Project: valproic acid. unable to add rxns to lims at this time. Drug Name: Valproic acid : PubMed Health: Valproic Acid (By mouth) Drug Classes: Anticonvulsant, Antimanic, Antimigraine : Drug Label: Valproic Acid is a carboxylic acid designated as 2-propylpentanoic acid. 2D Structure : Calculated Physico-chemical Properties : Hydrogen bond acceptors 2 Hydrogen bond donors 1 Rotatable bonds 5 Topological polar surface area 37.3 Molecular weight 144.12 XLogP 2.74 No. [1970 75; … 26 It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. Download . valproic acid — /val proh ik/, Pharm. Valproic acid, divalproex and valproate sodium are indicated in the treatment of simple and complex absence (petit mal) seizures. VALPROIC ACID . A value of zero indicates that no data are available. These are fatty acids with an acyl chain that has a methyl branch. 2-ene-Valproic acid, also known as 2-en-valproate or 2-ene-vpa, belongs to the class of organic compounds known as methyl-branched fatty acids. vlaw, Dec23/13 In 1962, the French researcher Pierre Eymard serendipitously discovered the anticonvulsant properties of valproic acid while using it as a vehicle for a number of other compounds that were being screened for antiseizure …
It is also known as dipropylacetic acid. Stars This entity has been manually annotated by the ChEBI Team. Click on a plot to see the median, interquartile range, low and high data points. Name: valproic acid. Log Octanol-Water Partition Coef (SRC): Log Kow (KOWWIN v1.67 estimate) = 0.33 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42): Boiling Pt (deg C): 480.37 (Adapted Stein & Brown method) Melting Pt (deg C): 203.43 (Mean or Weighted MP) VP(mm Hg,25 deg C): 1.11E-012 (Modified Grain … Name Divalproex sodium Drug Entry Valproic acid. 2-ene-Valproic acid. Related drugs include the sodium salts sodium valproate, used as an anticonvulsant, and a combined formulation, valproate semisodium, used as a mood stabilizer and …
valproic acid — noun The aliphatic carboxylic acid 2 propylpentanoic acid that is used as an anticonvulsant in the treatment of epilepsy etc … Wiktionary.
... 2-ene-Valproic acid. Valproic acid's clinical antimanic action require a lag period for onset and are not immediately reversed upon discontinuation of treatment, effects that suggest alterations at the genomic level; we therefore investigated the effects of valproic acid on the modulation of … History. valproic acid — /val proh ik/, Pharm. The compound has recently been shown to have activity as HDAC inhibitor. Metabolite 2-ene-Valproic acid. IUPAC Name: 2-Propylpentanoic acid Molecular Weight: 144,22 g/mol Molecular Formula: C8H16O2 SMILES: CCCC(C(=O)O)CCC Chemical Formula: C 8 H 16 O 2. click here for details. MOL SDF 3D-SDF PDB SMILES InChI.